Журнал онкологических исследований и лечения

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A Case of Malignant Melanoma of the Uterine Cervix

Mosse Wilfried BA, Oswald Houessou, Kietga Gael G, Hanan El-Kacemi, Tayeb Kebdani, Sanaa El-Majjaoui, Noureddine Benjaafar

Malignant melanoma of the cervix uteri is a rare cancer. It constitutes less than 2% of cases of malignant melanoma of the genital tract.

We reported a 52 years old woman with a 4-month history of peri-menopausal bleeding and leucorrhea. She had no medical history. The pathology of cervical punch biopsy showed malignant melanoma; the nuclei are frankly enlarged, rounded or oval, rarely irregular and always hyperchromatic with prominent nucleoli. There are some atypical mitoses and important melanic deposits. The final diagnosis was stage IIA1 primary cervical melanoma with involvement of the vaginal wall according to the International Federation of Gynecology and Obstetrics staging system (FIGO). She underwent a total colpohysterectomy expanded to the left lateral wall and the posterior wall of the vagina without pelvic lymph node dissection. The patient further underwent adjuvant fractionated radiotherapy to the pelvis with a dose of 50Gy; 2Gy/fraction, 5 sessions per week in 5 weeks.

In general, the prognosis of primary cervical melanoma is poor, because it is diagnosed at an advanced stage.