Журнал фармакокинетики и экспериментальной терапии

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A Short Review of Metabolism and Elimination Pathways of Drug Compounds

Xiong Chao

The metabolism and elimination of drug compounds play a crucial role in determining their efficacy, safety, and overall pharmacokinetic profile. This comprehensive study delves into the intricate pathways and mechanisms involved in the biotransformation of various drug compounds within the human body. Through an exploration of enzymatic reactions, conjugation processes, and organ-specific contributions, this study sheds light on how drug compounds are transformed into metabolites that can either retain or lose their pharmacological activity. Furthermore, the elimination processes, encompassing renal excretion, biliary secretion, and other clearance mechanisms, are examined to understand how these metabolites are efficiently removed from the system. A thorough understanding of these metabolic and elimination pathways is essential for optimizing drug dosing regimens, predicting potential drugdrug interactions, and minimizing the risk of adverse effects. This study amalgamates current research findings and provides insights into the pivotal role of metabolism and elimination in the field of drug development and therapeutic interventions.