Журнал терапии ожирения и снижения веса

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Adipocytes: Unveiling their Profound Impact on Obesity

Ravi Kiran

Adipocytes, the specialized cells responsible for storing and releasing energy in the form of fat, are key players in the development and progression of obesity. Beyond their role as passive energy reservoirs, adipocytes actively participate in regulating energy balance, metabolic function, and overall health. Adipocytes come in different types, with white and brown adipocytes playing distinct roles in energy metabolism. In obesity, adipocytes undergo expansion and dysfunction, disrupting the delicate balance of energy storage and release. Dysregulated adipocyte function leads to the secretion of adipokines and inflammatory molecules, contributing to systemic metabolic disturbances. Adipose tissue inflammation and immune cell infiltration further exacerbate the detrimental effects of dysfunctional adipocytes. Understanding the complex interplay between adipocytes, adipokines, and immune cells is crucial for developing effective strategies to combat obesity and its associated complications. Moreover, exploring the potential of brown adipocytes and their thermogenic properties offers promising avenues for innovative anti-obesity interventions. Further research into adipocyte biology holds the potential to uncover new therapeutic targets and interventions to address the global obesity epidemic and improve metabolic health.