Иммунология: текущие исследования

Абстрактный

Antibiotic Supplementation's Immunostimulatory Benefits on Asthma Patients: A Randomised, Double-Blind, Placebo-Controlled Trial

Dr. Clara Farrokhi

Background: Asthma is seen as an ongoing inflammatory condition of the airways. Living bacteria called probiotics are prevalent in the human stomach and have been shown to be protective against a variety of illnesses, including allergies. This study sought to better understand how probiotic treatment for asthma affected patients' clinical symptoms, changes in the expression pattern of specific microRNAs, and changes in plasma levels of IL-4 and IFN-.
Materials and methods: 40 asthmatic patients participated in the current investigation, which was a randomised,double-blind, placebo-controlled trial. Probiotics or a placebo was given orally once day for eight weeks. The expression of microRNAs, IL-4 and IFN- levels, and pulmonary function tests were evaluated before and after treatment.
Results: The findings demonstrated that probiotic supplementation dramatically decreased the expression of miR-16, miR146-a, and IL-4 levels in asthma patients while considerably increasing the expression of miR-133b.Furthermore, following taking probiotics, pulmonary function tests revealed a significantly improved Forced Expiratory Volume in 1 s and Forced Vital Capacity.
Conclusion: In our investigation, an 8-week probiotic supplementation regimen decreased IL-4 linked with Th2 cells and increased forced vital capacity and forced expiratory volume. The use of probiotics seems to be an option in addition to conventional asthma therapies.