Журнал цитокиновой биологии

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Antigen Presentation by MHC Class I Secrets of Cellular Immunity

Huyan Carrie

The structure, function, and significance of MHC class I molecules in antigen presentation and immune surveillance. Additionally, it discusses the mechanisms of antigen processing and presentation, the diversity of MHC class I alleles, and their implications in disease susceptibility and transplantation. Major histocompatibility complex (MHC) class I molecules play a crucial role in the immune system by presenting antigens to cytotoxic T cells. These molecules are expressed on the surface of nearly all nucleated cells and are responsible for presenting intracellular antigens derived from viral, bacterial, or tumor proteins. The binding of antigens to MHC class I molecules triggers an immune response, leading to the activation and proliferation of specific cytotoxic T cells that can eliminate infected or abnormal cells. Understanding the role of MHC class I molecules is essential for unraveling the complexities of immune responses and developing strategies for immunotherapy and vaccine design. MHC class I molecules are cell surface glycoproteins expressed on virtually all nucleated cells in the body. They play a critical role in the recognition and elimination of infected or malignant cells. The antigen presentation pathway mediated by MHC class I molecules allows the immune system to distinguish between self and non-self antigens, enabling the targeted destruction of infected or transformed cells while sparing healthy ones.