Журнал фармакокинетики и экспериментальной терапии

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Assessment of oxidative stress parameters in the kidney after the administration of nitrate in drinking water : an experimental study

Mahdi Jalali

Nitrate (NO3 -) is one of the inorganic anions produced from the oxidation of nitrogen. The organic or inorganic nitrogen may act as a carcinogen depending on the reduction of nitrate to nitrite and the subsequent reactions of nitrite with other molecules, leading to the formation of N-nitroso compounds. According to the results of the study, nitrate in drinking water and the prescription of Vitamin C had no significant effect in the presence of nitrate doses of 10 and 45 mg/L. However, a 200 mg/L dose of nitrate significantly affected BUN, serum creatinine, and oxidative stress indicators, causing the kidney disease.