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Bio-Active Transition Metal Ions are Involved in the Formation of Equilibria and Thermodynamic Stability of Multinuclear Amino Acid and Pyrimidine Base Chelates

V.P.Shukla

Coordination tendency of amino acid (valine) to form heterobinuclear complexes with some bi positive metal ions (CoII, NiII, CuII, ZnII) in presence of pyrimidine base (Uracil) have been explored potentiometricallyin aqueous medium. Formation constants of the complexes at 37±10 and at constant ionic strength 0.1 NaNO3 have been evaluated using SCOGS computer program. Solutions of Cobalt, Nickel, Copper, Zinc, metal ions (0.01M) were prepared and standardized by EDTA titration. The solution of uracil (0.01M) was prepared by dissolving the ligand into one equivalent of alkali sodium hydroxide, whereas valine solution (0.01M) wasprepared in double distilled water only. The speciation curves are finally sketched by running computer program ORGIN4.0. The overall stability constants of binary, ternary and multinuclear chelates follow Irving William Order. Titration and speciation distributioncurves werefound to be favourable for the complexation.