Международный журнал воспаления, рака и интегративной терапии

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Bone Health in Metabolic Endotoxemia Related Obesity

Aliya IS, Norhazilah M, Faruk RM, Amanov M, Mariam IU, Zainab M, Gotam K, Nordin S and Atif AB*

Obesity is a multifactorial disorder leading to multiple metabolic complications including hypertension, hypercholesterolemia, atherosclerosis, insulin resistance, type II diabetes and fatty liver. Recent research has discovered that obesity is associated with systemic low grade inflammation and one of the contributing factors can be alteration of gut microbiota due to change in dietary habits; attributed to high fat and carbohydrate diet. This altered microbiota brings along circulating lipopolysaccharide (LPS) which plays a key role in initiating low grade inflammation in adiposity associated with release of certain cytokines such as tumor necrosis factor (TNF) and interleukins especially interleukin1 (IL1) and marked by high C reactive protein, haptoglobulin alpha 1 acid glycoprotein (AAG) and alpha 1 antitrypsin (AAT) . In in this review we have focused on mechanism through which metabolic endotoxemia due to altered gut microbiome in obesity can also affect bone health and hinder bone formation. In addition to this exploring th possibility that increased leptin and decreased Vitamin D in obesity may supplement the bone loss.