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Breast Carcinoma Metastasis to the Submandibular Glands in a Male Patient: A Case Report and a Literature Review

Srbislav Pajic, Drazen Radanovic, Dragan Vasin, Pavle Pesic, Farah Hamzagic, Ivan Krunic

Female breast cancer is the most frequently diagnosed tumor while in the male population breast cancers are uncommon, as men account for less than 1% of all breast carcinomas. The leading predisposing factors for the development of breast cancer in men are: (1) chest radiation exposure, (2) estrogen use, diseases associated with hyperestrogenism, such as cirrhosis or Klinefelter syndrome, and (3) family health history. Male breast cancer (MBC) is more prevalent in elderly men. It occurs most often in the elderly population and resembles postmenopausal breast cancer in women based on its behavior. A higher incidence of breast cancer was recorded in men who have a larger number of relatives with BRCA mutations in the family, although the risk appears to be greater with inherited BRCA-2 mutations than inherited BRCA-1 mutations. Breast cancer rarely metastasizes to the oral region. If metastases occur in the oral region, they are localized in the maxillary and mandibular bones, less often in soft tissues. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. We describe a case of breast cancer metastasis to the submandibular glands. Examination of both masses of a 75-year-old Serbian male patient in both of the submandibular glands was suggestive of breast cancer metastasis, and a breast tumor mass was detected. We decided on operative treatment and successfully removed the tumor masses