Журнал болезни Альцгеймера и паркинсонизма

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Can SARs-CoV-2 Infect Nasal Epithelium and Cause Parkinson's Disease?

Mohsen Rafie, Farhad Azadmehr, Mostafa Taheri, Aylar Mansouri4, Valentyna Mahdi Naeim

Background: The main trigger for Parkinson's disease is a mutated version of a protein called alpha-synuclein. This protein accumulates in dopamine-producing neurons. COVID-19 can increase the risk of Parkinson's and other neurological diseases.

Materials and Methods: This research study was conducted by the library method.

Results: The results showed that the virus can cause neuroinflammation, which, as a predisposing event, predisposes the brain to overreaction to subsequent neurological events. This secondary neurological event can be anything from another viral infection to poisoning and even aging. A secondary neurological event triggers an abnormal brain response that leads to nerve degeneration and eventually Parkinson's disease. The results show that the SARS-CoV-2 virus as a neurotropic virus can enter brain tissue.

Conclusion: Therefore, the virus certainly has the potential to act as a predisposing event in increasing the risk of Parkinson's disease.