Исследования биополимеров

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Cellular uptake and cytotoxicity studies of pH-responsive polymeric Nano particles fabricated by dispersion polymerization

Reema Puri, Simeon Adesina, Emmanuel Akala

Puri R, Adesina S, Akala E. Cellular uptake and cytotoxicity studies of pH-responsive polymeric Nano particles fabricated by dispersion polymerization. A strategy in site-specific drug delivery is the use of pHgradients that exist in diseased conditions such as cancer for the release of loaded drug(s) in the biophase. The objective of this work is to synthesize pH-responsive docetaxel-loaded Nano particles with a bisacrylate acetal crosslinker, which can get internalized into cells, and which will be equivalent to or more cytotoxic than the free drug against cancer cells.