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Cyclin D1 G870A Polymorphism is Associated with an Increased Risk of Simple Endometrial Hyperplasia in Egyptian Women

A.F. Abdel Aziz, A. A. El-Refaeey, Afaf M Elsaeid and Manar Refaat

Endometrial hyperplasia (EH) is a common diagnosis in women presenting with abnormal uterine bleeding, leading to cancer if untreated. Cyclin D1 A870G polymorphism was associated with increased risk of endometrial carcinoma, but no reported study has evaluated the association between the cyclin D1 A870G polymorphism and the risk of EH. We aimed to study the association of cyclin D1 A870G polymorphism with the risk of simple endometrial hyperplasia (SEH) in Egyptian women. Results showed that A allele was associated with a significantly elevated OR of 3.2 (95% CI =2.15 -5.01, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 4.03 (95% CI = 2.3 -7.1, P = 0.000) in premenopausal cases, as well as postmenopausal cases (OR of 2.3, 95% CI = 1.18-4.4, P = 0.01). Using the GG genotype as the reference genotype, the AA genotype was associated with a significantly elevated OR of 8.9 (95% CI = 3.7-21.5, P = 0.0001) in SEH cases, and was found to be associated with a significantly elevated OR of 16.4 (95% CI = 4.8-55.5, P = 0.000) in premenopausal cases as well as post-menopausal cases (OR of 4.6 (95% CI = 1.18-18.1, P = 0.02). In conclusion, the common G to A polymorphism in the CCND1 gene is associated with an increased risk of simple endometrial hyperplasia.