Журнал клеточной и молекулярной фармакологии

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Decoding the Mitochondrial Dance Insights into Apoptotic Regulation

Monireh Soltani*

This article explores the fascinating realm of the mitochondrial pathway in apoptosis, often likened to a meticulously choreographed dance within our cells. By decoding this intricate dance, we gain profound insights into the regulatory mechanisms that determine cellular fate. The primary actors in this performance are the mitochondria, the Bcl-2 family proteins, cytochrome c, and caspases. The dance unfolds in a sequence of precisely orchestrated steps, from the modulation of mitochondrial permeability to the release of cytochrome c and the activation of caspases. Understanding this mitochondrial dance holds significant implications, especially in cancer research, where dysregulation of apoptosis contributes to uncontrolled cell proliferation. This article provides a glimpse into the captivating world of the “Mitochondrial Dance” and its potential therapeutic implications