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Development of Combined Transdermal Patch Formulations Incorporating Salbutamol Sulfate and Ketotifen Fumarate for Respiratory Conditions

Mustafa Soylak

Salbutamol sulfate and ketotifen fumarate are widely used medications for the treatment of respiratory conditions, such as asthma and allergic rhinitis. In this study, we aimed to develop a novel combined transdermal patch formulation containing both salbutamol sulfate and ketotifen fumarate. The transdermal patch offers several advantages over conventional oral dosage forms, including improved patient compliance, sustained drug release, and reduced systemic side effects. The formulations were prepared using a blend of polymers, permeation enhancers, and drug-loaded reservoirs. Physicochemical characterization, in vitro drug release studies, and skin permeation studies were conducted to evaluate the performance of the transdermal patches. Furthermore, the stability of the formulations was assessed over a predetermined period. The results demonstrated that the developed transdermal patches exhibited sustained drug release profiles of both salbutamol sulfate and ketotifen fumarate, and demonstrated satisfactory permeation through the skin. The stability studies revealed that the formulations maintained their integrity and drug content throughout the storage period. These findings suggest that the developed combined transdermal patch formulation has the potential to provide a convenient and effective treatment option for respiratory conditions.