Журнал болезни Альцгеймера и паркинсонизма

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Diagnosing Progressive Supranuclear Palsy: Role of Biological and Neuroimaging Markers

Borroni B, Benussi A, Pilotto A, Gazzina S, Turrone R, Gardoni F, Di Luca M and Padovani A

Progressive Supranuclear Palsy (PSP) is a neurodegenerative disorders characterised by a kinetic-rigid syndrome with ocular motor dysfunction, postural instability, and frontal lobe and bulbar dysfunction. In most of the cases, especially at early disease stages, diagnosis is still challenging. PSP signs and symptoms may indeed overlap with both dementing neurodegenerative syndromes and movement disorders. In the last few years, a better definition of clinical picture along with the identification of biological and neuroimaging markers have increased diagnostic accuracy. In the present work, we reviewed the current literature on PSP diagnosis and the usefulness of potential diagnostic markers.