Журнал клеточной и молекулярной фармакологии

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Drug Metabolism, Effectiveness, and Toxicity Interactions with the Gut Microbiota

Eduard Barba

Whether or now not an individual’s drug metabolising potential declines with advancing age is a vexing question. There is no clear proof that drug metabolism itself (‘the biologically-assisted chemical alteration of the administered mother or father molecule’) is much less environment friendly in healthful historical age than at youthful ages, whereas a diminished potential may also be related with ill-health and frailty. However, aged persons do exhibit decreased enzyme induction functionality and are much less capable to tolerate overdoses. It seems that the majority of deleterious medical effects associated to drug remedy in an aged (usually unwell or frail) populace may additionally be ascribed to quite number anatomical and physiological age-related changes. These can also have an effect on both pharmacodynamics and pharmacokinetics, however no longer always drug metabolism.