Клеточная и молекулярная биология

Абстрактный

Effect of Vitamin D3 (25-OH Cholecalciferol) Therapy on Clinical Status in Adult Bahraini Patients with Systemic Lupus Erythematosus

Adla B Hassan, Eman Farid, Ahmed A Jaradat and Ola Al-Segai

The relationships between serum levels of Uric Acid (UA) and vitamin D3 (25-OH Cholecalciferol) in systemic lupus erythematosus (SLE) have been revealed separately; however, a possible link between these two factors and their interaction with SLE severity has not been clarified yet. This is the first study on investigating the conjoint association of vitamin D3 and UA on disease activity in Bahraini patients with SLE. Objectives: To evaluate serum UA and serum vitamin D3 (VD) as important factors in clinical status in adult Bahraini patients with SLE and to look into the possible correlation between these two factors and their relation to disease activity in this patient’s group. Materials and methods: Fifty-one adult Bahraini SLE patients (mean age of 40.8 years, females were 84.3%) were included in this retrospective longitudinal (two-time points) study. Blood samples were taken before and after VD therapy 2-3 months apart at Salmanyia Medical Complex. All patients received oral VD therapy in form of tablets (50.000 IU) once per week for a maximum period of 3 months. Blood samples were obtained for determination of serum levels of VD, calcium, phosphorus, alkaline phosphatase (ALP) and parathyroid hormone (PTH), but also for serum UA, complements (C3 and C4), C-reactive protein (CRP), antinuclear antibodies (ANA) and anti-doublestranded (ds)- DNA antibody. Results: The current study showed that VD therapy bring about two-fold increment in its mean serum level (p<0.0001) with increased in serum calcium (p<0.05). Wonderfully, the mean serum levels of ds-DNA auto-antibodies and UAUA were significantly decreased after VD therapy (p=0.015 and p=0.010, respectively). Interestingly, when the group was segregated by gender and age; the female group and the age group ​