Журнал терапии ожирения и снижения веса

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Effects of Fish Oil on Cytokines, Glycemic Control, Blood Pressure, and Serum Lipids in Patients with Type 2 Diabetes Mellitus

Reza Rastmanesh, Afrooz Javidi, Fourough A Taleban, Masood Kimaigar and Yadollah Mehrabi

Objective: We examined the ability of dietary fish oil to suppress markers of inflammation and consequent effect(s) on serum fasting glycemia, lipids, and blood pressure in patients with T2DM. Design: Correlations between serum fasting interleukin-6, Interleukin-1β (IL-1β), TNF-α (TNF-α), C-reactive Protein (CRP), and sialic acid, with indices of glycemia, insulin, and lipids were determined in 26 patients with T2DM at baseline, 4 weeks and 8 weeks after supplementation with fish oil (3 g/d) to analyse possible correlations between markers of inflammation and indices of glycemia. Results: There were no significant correlations between markers of inflammation with indices of glycemia at baseline, 4 weeks and 8 weeks after fish oils supplementation. Serum CRP concentrations were negatively correlated with fasting serum LDL, and with Cholesterol (r=-0.424, P<0.04; r=- 0.447, P<0.03, respectively). Fasting IL-1 β concentrations were positively correlated with fasting LDL, and with cholesterol at week 4 (r=0.482, P<0.02; r=0.469, P<0.02, respectively). There were no significant correlations between serum lipids with markers of inflammation at the end of intervention. There were no significant changes in serum fasting insulin, and glucose concentrations at the end of the intervention. Conclusions: A moderate dose of fish oil did not lead to deleterious effects on glycemic control in patients with T2DM, with preserved triacyglycerol-lowering capacities.