Клинические инфекционные заболевания и практика

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Endogenous retroviruses: Anti-bacterial biogenesis pathways of RNAs

Changyong Zhou

Endogenous retroviruses area unit relics of ancient infections from retroviruses that managed to integrate into the ordering of germline cells and remained vertically transmitted from parent to issue. Beyond the endogenization method, these sequences will move and multiply within the host ordering, which might have hurtful consequences and disturb genomic stability. Natural process favored the institution of silencing pathways that shield host genomes from the activity of endogenous retroviruses. Ribonucleic acid silencing mechanisms area unit concerned, that utilize piRNAs. The response to exogenous infective agent infections uses siRNAs, a category of tiny RNAs that area unit generated via a definite biogenesis pathway from piRNAs. However, interaction between each pathway has been known, and interactions with anti-bacterial and anti-fungal immune responses are suspected. This review focuses on animal order (Arthropods) and intends to compile items of proof showing that the ribonucleic acid silencing pathway of endogenous animal virus regulation isn't freelance from immunity and also the response to infections. This review can think about the mechanisms that enable the lasting beingness of infective agent sequences Associate in Nursing host genomes from an organic process perspective.