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Endothelial Progenitor Cell Number to Apoptotic Endothelial Cell-Derived Micro Particles Ratio in Chronic Heart Failure Phenotypes

Alexander E. Berezin

Heart failure (HF) remains a leading cause of cardiovascular (CV) mortality and morbidity worldwide. Endothelium is considered a target organ that is involved in the pathogenesis of HF at the earliest stages and corresponds to CV risk factors, CV diseases and different phenotypes of HF. Endothelial progenitor cells (EPCs) with pro-angiogenic phenotypes and apoptotic endothelial cell-derived microparticles (EMPs) may reflect the severity of endothelial dysfunction and predict HF phenotypes. Moreover, apoptotic EMPs and EPCs are involved in the function of endogenous endothelial repair system, which contributes in the pathogenesis of HF across all stages. The short communication is dedicated the predictive role of altered ration between both biomarker of HF in the way to individualize the contemporary predictive score.