Журнал радиологии OMICS

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Evaluating Quality Control of Radiotracer 18F-FDG: Experience in the United Hospital, Bangladesh

Samiya Mahjabin, Tarana Mahzabin, Zahid Hasan Mahmood and MA Wahab

In the present research the quality of 18F-FDG (fluorodeoxyglucose) is maintained to reduce hazards of the patients and produce good quality of image that helps interpret the image with proper diagnosis. The quality of produced 18F-FDG in the United Hospital, Bangladesh is checked in the quality control laboratory and compared with the guideline criteria of the International Atomic Energy Agency. This 18F-FDG has been injected into 2500 patients and found no immediate or afterward hazards to any patients till now. Radionuclide purity, radiochemical purity, chemical purity, pH are assessed to have the quality assurance of 18F-FDG studied. Radionuclide purity is validated by half-life measurement and gamma ray detection. The calculated average half-life (110.26 min) and halflife 18F (109.7 min) are found in good agreement. The peak from TLC result sheet gives only the peak of unhydrolyzed FDG which implies more than 99% 18F-FDG is evident in this experiment. Chromatographic spectrum of residual solvents like Acetonitrile and Ethanol are analyzed to access the chemical purity with respect to permissible concentration. The pH of 18F-FDG is found within 4.5 to 6.5.