Журнал молекулярной фармацевтики и исследований органических процессов

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Excessive Intake Salt Contribution to Cognitive Impairment in Mice

Yu LJ, Wan P, Wang D, Bian M, Bao SY and Gong GH

Dementia mice model was prepared by D-gal, Morris water maze was used for behavior research; c(WB) method was used for the pre-dementia protein expression research. Results showed that excessive intake of salt significantly decreased the memory ability and significantly prolonged the escape time and distance to get the platform; WB results showed that expressions of beta amyloid (Aβ) and β-site APP cleaving enzyme 1 (BACE1) significantly increased and the NEP expression significantly decreased under the condition of excessive salt intake. Results suggest that excessive salt intake can regulate the protein expressions of Aβ, BACE1 and neprilysin to enhance D-gal-induced dementia.