Журнал клинического диабета

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Failure to develop Tolerance to Thyroid Peroxidase at an Early Age and a Strong Ctla-4 Gene Association Define Female-Dominated Type 1 Diabetes Subgroup

Philip Durrell

Type 1 diabetes and autoimmune thyroid disease (AITD) have been linked to HLA haplotypes with allelic variation of the T cell activation gene PTPN22 and the T cell regulatory gene CTLA4. We compare the relationship between these loci and type 1 diabetes patients with and without thyroid peroxidase autoantibodies (TPOAbs), an indicator of thyroid autoimmunity. People with type 1 diabetes from all over Great Britain had their TPOAbs measured. 67% were under the age of 18. Genotyping was done on these cases and controls from the same area.