Журнал молекулярной фармацевтики и исследований органических процессов

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Formulation and Evaluation of Fast Dissolving Tablets of Diclofenac Sodium by Novel Hole Technology

Renati Damodar, Babji Movva, Mallikarjun PN, Chaitanya Pasumarthy, Nishanth Kona and Varsha PV

Research has done to prepare Diclofenac Sodium quick dissolving tablets by Hole technology. Once these quick dissolving tablets contact with gastro enteric fluids, the fluid can enter the hole within the tablet and immediate breaking of the tablet goes to take place. This quick disintegration of tablets is additionally influenced by the formation of latest absolute space. The ready FDTs were subjected to numerous pre and post formulation studies. Its disintegration and dissolution rates were compared with the management formulation (without hole). In-vitro drug release of FDTs (DH6) showed virtually 100.92% of the drug was discharged at sixth minute, whereas the management formulation D12 shows the 99% drug release at 20th minute. Overall, this method is novel and most helpful for formulation into quick dissolving tablets.