Журнал клинической и экспериментальной патологии

Абстрактный

Formulation and Phytopharmacological Activity Studies of Fresh Juice of Acacia arabica Stem and Leaves for the Treatment of Variety of Dental Problems

Shinde SA, Chavhan SA, Bute SD, Rangari VD

It is well known that use of plant material for oral healthcare and treatment of periodontal disorder is common in many cultures and many of such remedies are very effective with respect to long term health. From literature review, it comes to know that Acacia arabica stem is used as chewing stick and claimed to be useful for health of gum. The objective of the proposed study is to perform the phytochemical studies on the fresh juice of babul stem and leaves. It is further envisaged to study anti-inflammatory, analgesic and antimicrobial properties of the dried fresh juice. Objective shall further be extended to convert the dried fresh juice to a suitable formulation for the treatment of variety of dental problems. Phytochemical tests suggest presence of carbohydrates, steroids, tannins and flavonoids in leaf and stem juice both. Leaf juice at the dose of 200 mg/kg bodyweight was found to be very effective in imparting analgesic effect. In the anti-inflammatory studies leaf juice at the doses of 50 mg/kg, 100 mg/kg and 200 mg/kg body weight was effective to reduce inflammation. The activity of leaf juice was more than that of stem juice but both can be claimed to have analgesic and anti-inflammatory activity. The activity may be due to presence of tannins, steroids and flavonoids. The dry juice was incorporated into a mouthwash formulation at 1% leaf juice, 1% stem juice and 1% leaf and stem juice both of which formulation no. 3 with leaf and stem juice 1% both was better in taste, odour and colour.