Журнал диабета и клинической практики

Абстрактный

Genetics of the Endocrine System that Produces Vitamin D

Rowan Dean

The endocrine system plays a pivotal role in the production of vitamin D, a crucial hormone for maintaining various physiological processes in the human body. The genetics underlying the endocrine system's ability to synthesize vitamin D are complex and multifaceted. This abstract provides a brief overview of the genetic factors influencing vitamin D production. A significant component of the endocrine system is responsible for converting sunlight into vitamin D through a photochemical reaction involving 7-dehydrocholesterol. CYP2R1 is involved in converting vitamin D into its active form. Polymorphisms in the CYP2R1 gene can impact an individual's ability to convert vitamin D, potentially leading to vitamin D insufficiency. Additionally, genes associated with skin pigmentation, such as that regulating melanin production, can influence the amount of UVB radiation absorbed by the skin, affecting vitamin D synthesis. Understanding the genetic factors affecting vitamin D production is crucial for addressing variations in vitamin D levels among individuals and populations, enabling personalized approaches to address vitamin D deficiency and optimize human health.