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HDAC Allostery: A Therapeutic Target for the Management of Diabetes and Its Complications

Nurudeen Owolabi

A few decades ago, Diabetes Mellitus (DM), as well as its complications was and till date, remains, a threat to the medical and economic sectors of the world. DM is a polygenic metabolic syndrome with varying types, which include type 1 DM, type 2 DM, and Gestational Diabetes Mellitus (GDM). These have different etiologies but share similar symptoms. Though the full pathogenesis of DM is yet to be unraveled, it is of great importance to note that a strong genetic correlation exists between HDAC and DM and its associated complications. HDAC is a superfamily of enzymes that function in the catalytic removal of acetyl groups from Ɛ-amino groups of lysine residues. It is believed that targeting HDAC with the use of HDAC inhibitors will be a key tool to regulate the catalytic function of HDAC towards ameliorating or reversing the complications associated with DM. In this review we summarize the forms of dabetes, classes of HDAC relationship between etiology of diabetes and HDACi Insulin resistance and HDACi and pharmacological target of HDAC.