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Hematological Alteration Induced After Intramuscular Administration of Long Acting Moxifloxacin in Sheep

CM Modi, SK Mody and HB Patel

Aim: The present study was carried out to investigate hematological alterations induced after single intramuscular administration of long acting moxifloxacin at the dose rate of 7.5 mg/kg body weight in six healthy male sheep. Materials and methods: Blood samples were collected from treated animals from jugular vein into K2EDTA tubes at 0, 6, 12 hour and 2th, 3rd, 4th, 5th, 6th, 7th day after treatment were analyzed for hematological parameters (total leukocyte count, differential leukocyte count, total erythrocyte count, Hemoglobin, HCT, MCV, MCH, MCHC, RDW and MPV) analysis. Results: The results of the study clearly demonstrated that single intramuscular administration of long acting moxifloxacin in therapeutic dose produced non-significant difference (p<0.05) in values of hematological parameters in sheep when compared with control values (0 day). Conclusion: Lack of clinical signs of adverse reactions and absence of significant difference hematological alteration following intramuscular administration may be open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in sheep.