Журнал цитокиновой биологии

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Immunogenetics: Unravelling the Genetic Blueprint of Immune Responses

Adam Cristiano

Immunogenetics, an interdisciplinary field at the nexus of immunology and genetics, investigates the genetic
determinants influencing immune responses and disease susceptibility. This abstract provides an overview of the
fundamentals of immunogenetics, highlighting the significance of the major histocompatibility complex (MHC) and
human leukocyte antigen (HLA) system. Genetic polymorphisms impacting disease susceptibility, vaccination
responses, and transplantation outcomes are explored. The article discusses the application of immunogenetics in
personalized medicine, including tailored immunotherapies and precision vaccinology. Genomic approaches, such
as genome-wide association studies (GWAS), contribute to a nuanced understanding of the genetic underpinnings
of immune-related traits. Challenges in deciphering the complexity of immune responses and future directions
in functional genomics are also addressed. Immunogenetics emerges as a cornerstone in the era of precision
medicine, offering insights that reshape our approach to healthcare.