Журнал клеточной и молекулярной фармакологии

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Impact of Aerosols on Liver Xenobiotic Metabolism: A Comparison of Two Methods of Exposure

William Harvey* and Stephen Hawking

Exposure to aerosols, which are suspended particles in the air, has been identified as a potential risk factor for liver health due to their ability to carry various xenobiotic compounds. This study aimed to investigate the impact of aerosols on liver xenobiotic metabolism and compare the effects of two different exposure methods. The study utilized an animal model and divided the subjects into two groups: Group A was exposed to aerosols through inhalation, while Group B was exposed to aerosols through dermal contact. After exposure, liver tissue samples were collected, and various parameters related to xenobiotic metabolism, including enzyme activity and gene expression, was assessed. The results revealed significant alterations in liver xenobiotic metabolism in both exposure groups compared to the control group. However, notable differences were observed between the two exposure methods. Group an exhibited higher levels of oxidative stress markers and elevated activity of phase I metabolic enzymes, suggesting increased xenobiotic biotransformation. In contrast, Group B demonstrated upregulated expression of phase II metabolic enzymes involved in conjugation reactions, indicating enhanced detoxification processes.