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Impact of Microenvironment in Therapy-Induced Neovascularization of Glioblastoma

Bhagelu R. Achyut

Therapy induced neovascularization is an emerging cancer hallmark, which has been observed during the antiangiogenic treatments (AATs) to suppress angiogenesis in glioblastoma and other cancers. Clinicians and researchers have following major questions such as (1) why the AATs are inducing unwanted vasculature? (2) What are the molecular mechanisms associated with this daunting outcome? (3) What are signature targets to combat tumor angiogenesis or vasculogenesis? Focused strategies to investigate these aforementioned questions are required to answer to proceed further. Recent studies have shown the importance of microenvironment in the regulation of angiogenesis and/or neovascularization both at cellular and molecular levels. Better agents with broad range of targets could help to reprogram the tumor microenvironment as well as to combat the tumor and therapy induced neovascularization.