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Impairment of Normal Endothelial Cell Function Plays a Major Role in the Initiation and Advancement of Cardiovascular Disease

Saira Munawar

Endothelial dysfunction is a significant factor in the development and progression of cardiovascular disease. Microparticles (MPs) derived from endothelial cells are considered to be biological markers of endothelial injury and repair, and could potentially serve as useful predictors of clinical outcomes. Apoptotic endothelial cell-derived MPs have been shown to contribute to microvascular inflammation and worsening of endothelial integrity, whereas endothelial MPs originating from activated endothelial cells may promote vascular repair and vasodilation.