Журнал болезни Альцгеймера и паркинсонизма

Абстрактный

Inflammatory Cytokines in a Sample of Alzheimer's Patients from Rio De Janeiro State

Luiz Felipe da Silva Figueiredo, Creso Almeida, Luciana Silva Rodrigues, Patricia Maria Lourenco Dutra, Jerson Laks

We carried out an evaluation of a sample of 45 elderly into 2 groups GA(21)=75.9+7.4 years and GC(24)=75.3+7.5 years. We evaluated CDR, MMSE, and CST, Lawton and Brody Scale and one sample of 5 ml of blood for analysis of biomarkers. The data were compared between groups. The results showed higher levels for IL-12, IL-10 and IL-1β for Alzheimer’s disease. IL-10 was correlated with age, CDR and functional capacity and negative correlated with MMSE. The age was correlated with TNF-α, IL-10, IL-4. The CST was correlated with IL-4. We conclude that Alzheimer’s disease changes de immune system with higher inflammatory cytokine and correlated with functional and cognitive capacity impacting the elderly health.