Журнал болезни Альцгеймера и паркинсонизма

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Invasive Rhino-Orbital-Cerebral Mucormycosis in Sinonasal Neuroendocrine Carcinoma: A Case Report

Sherin Mary Philip

Mucormycosis is an invasive infection due to Mucorale species with an acute onset and have potential to be life-threatening. Though a relatively uncommon fungal infection in comparison with candidiasis and aspergillosis, mucormycosis cases have been on the rise over the past decade possibly due to the increased use of chemotherapy, steroids and other immunosuppressants which is associated with prolonged immunocompromised state. Neuroendocrine carcinoma is a rare malignancy of specialised cells called neuroendocrine cells having both hormones producing as well as nerve cells which can occur anywhere in the body. Surgical intervention and debridement is the gold standard of treatment for eradicating the infection along with antifungal treatment with Liposomal Amphotericin B formulations and Posaconazole. We report a case of a diabetic woman with sinonasal neuroendocrine cancer who developed mucormycosis recovered with appropriate intravenous antifungal therapy.