Журнал диагностики рака

Абстрактный

MicroRNAs: New Roles in Cancer Treatment and Diagnosis

Reza Jamal

Small no protein-coding RNAs called microRNAs control the expression of a wide range of genes by basepairing on the untranslated region (UTR) of their target mRNAs, which either causes the target mRNA to degrade or inhibits its translation. In human breast cancer, aberrant miRNA expression has been associated with tumour formation, metastasis, diagnosis, prognosis, and therapeutic response. Certain miRNAs have been thought to have potential clinical uses as a diagnostic and therapeutic tool for breast cancer. Here, we outline and discuss the several lines of evidence that point to the critical connection between miRNAs and breast cancer, as well as its treatment options.