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Nutrimiromics: A Possible Answer for Premature Ovarian Failure

Mona Sharma

Nutrimiromics studies the effect of dietary factors on modulation of miRNA expression which leads to disease development. Studies have confirmed their role in immune modulation and their ability to get transferred themselves in other tissues where they influence tissue specific functions. These functions are conducted by means of their transfer in extracellular vesicles such as exosomes. Exosomes deliver their contents such as miRNAs to recipient cells. Micronutrients/Dietary trace elements are essential components for various biological processes. Dietary deficiency of trace elements has shown to alter various reproductive functions including folliculogenesis. Altered folliculogenesis causing oocyte atresia is the major etiopathological change ultimately leading to premature ovarian failure (POF). POF is a primary ovarian defect with symptoms of absent menarche or cessation of menstruation, infertility and symptoms of physiological menopause due to low estrogen levels before the age of 40 years. Dietary trace elements alter miRNA expression and disease processes. As the trace elements are essential for folliculogenesis, their association with ovarian failure is highly suggested.