Клиническая фармакология и биофармацевтика

Абстрактный

One Internal Secretion, Two Actions: Glucocorticoids' Anti- and ProInflammatory Effects

Greenery Ancola

The medicine activity of glucocorticoids is attributed to the repression of pro-inflammatory genes through signal transduction by their steroid receptor, the internal secretion receptor (GR). The mechanisms modulating the proinflammatory effects of glucocorticoids are not well understood. Throughout this review, we have a tendency to tend to debate recent findings that provide insights into the mechanism by that GR sign can play a twin role among the regulation of the immune response. we have a tendency to tend to theorize that these apparently opposite processes unit of measurement operational on to prepare the system to reply to a agent (pro-inflammatory effects) and once restore state (anti-inflammatory effects). Finally, we have a tendency to tend to propose that determinant the mechanisms that underlie the tissue-specific effects of hormones offers an exquisite tool to develop plenty of economical and selective hormone therapies.