Журнал клинической и экспериментальной патологии

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Pelvic Girdle Myopathy Caused by Isotretinoin: Case Report and Discussion of Pathophysiology

Janati A, AL Ghasab Naif S, Sofiane Ghorbel, Budoor A. Al-Emadi, Kareemah S. Al-Shurtan, Abdulmohsen S. Alghassab, Lila S. Seada, Muhammad Umair, Nour M Alfahhad and Hani al shubaili

Introduction: Isotretinoin is the mainstay therapy for severe and nodulocystic acne. Myalgia and muscle stiffness have been reported in 16-51% of patients treated with isotretinoin, while elevated serum Creatine Kinase (CK) levels have been found in up to 41%. In this paper, we report, for the first time, the occurrence of myopathy limited to the pelvic-girdle muscles in a teen who received isotretinoin therapy.
Methods: This was a case study conducted at King Khalid Hospital.
Results: Histopathology and other laboratory data were consistent with an inflammatory myopathy based on a vasculitic process.
Conclusion: Our data indicate that the myopathy caused by isotretinoin is an inflammatory process based on vasculitis, resulting in ischemic muscle necrosis.