Журнал беременности и здоровья детей

Абстрактный

Promoting Of Ovarian Cancer of Role and Hallmarks of Sp1

Angel Yadav

A late diagnosis, intrinsic drug resistance, and rising interest in discovering novel DNA binding and transcription factor agents as potential therapies in treating ovarian and other gynaecological cancers are all contributing factors to the poor prognosis of ovarian cancer. A deeper knowledge of Sp1's role in the initiation and progression of human cancer is still needed, but it is clear from several prior publications that Sp1 controls the expression of many cellular genes. Sp1 has been discovered to have a dual role, activating and suppressing cellular genes that could otherwise become oncogenes or engage in biological processes like proliferation, differentiation, DNA damage response, apoptosis, and angiogenesis. In fact, there are indications that Sp1 has identical protein variants known as Sp2 and Sp3 support Sp1 in promoting the growth of tumour cells.