Журнал аналитических и биоаналитических методов

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Proteomics– Current Novelties and Future Directions

Sara ten Have, Yasmeen Ahmad and Angus I Lamond

Increasingly in the last decade, proteomics has become a widely used technique in the field of cell biology. This is due not only to improvements in technology and analytical procedures, but also because of the innovative and diverse ways in which the methodologies of protein and peptide analysis have been applied. This has resulted in the broadening of applications and potential uses for proteomics, including analyses of cellular substructures and mechanisms to imaging of protein distributions in cells and tissues. The growing scale and scope of modern proteomics projects has brought to the fore computing challenges involved in managing and mining the resulting very large and complex data sets. Modern proteomics is therefore inherently multidisciplinary, requiring the expertise of software engineers and statisticians as well as cell biologists, protein chemists and mass spectrometrists. This review article will describe some of the elegant, quirky, and novel applications of mass spectrometry based proteomics to medical research, diagnostics, quality control and drug discovery.