Журнал терапии ожирения и снижения веса

Абстрактный

Relationship between body mass index and fifteen classical markers of the metabolic syndrome in young adults of western Algeria

M I Belhayara

Obesity plays a critical role in metabolic complications seen in metabolic syndrome populations. Yet, the consequences of increased body mass index on the metabolic disorders assiociated with metabolic syndrome have not been thoroughly examined. Fifteen classical markers of the latter syndrome, as well as body mass index, were measured  in both 20 non-obese and 20 obese control subjects and 20 overweight and 80 obese young adults of western Algeria affected by the metabolic syndrome. The possible interrelationships between body mass index and selected markers was then investigated. Even in control subjects as distinct from patients affected by the metabolic syndrome, obesity coincides with obvious increases of glycemia, insulinemia, HOMA index, total cholesterol, triglycerides, leptin and hs-CRP and obvious decreases of adiponectin and GLP-1. Qualitatively, the obese control subjects display virtually all the perturbations of metabolic variables considered as indicative of the metabolic syndrome. Such a finding reinforce the view that obesity, as most currently attributable to an imbalance between food intake and energy expenditure, may well represent, in most patients affected by the metabolic syndrome, a key pathological determinant. Hence, the present finding also argue in support of a dietary approach in the perspective of preventing, or even curing, the metabolic syndrome.