Журнал фармакокинетики и экспериментальной терапии

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Resistance to Antifungal Drugs Evolution, Causes, and Consequences

Kali M Revie

Resistance to antifungal drugs is a growing concern in the field of medical mycology and public health. As the use of antifungal agents becomes more widespread, fungal pathogens are evolving mechanisms to evade their effects, rendering once-effective treatments ineffective. This evolution of resistance is a multifaceted process driven by various factors, including genetic mutations, overuse and misuse of antifungal agents, and environmental pressures. In this review, we explore the current state of antifungal drug resistance, its underlying causes, and the potential consequences for patients and healthcare systems. Understanding the dynamics of antifungal drug resistance is crucial for developing strategies to mitigate its impact and preserve the efficacy of these essential therapies.