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Review of In Situ Immunopathological Occurrences in Cervical Cancer and Intraepithelial Neoplasia in Humans

Alexander Barba

Immunosuppressive treatment of organ transplant recipients is associated with an increase in the occurrence of human papillomavirus (HPV) related anogenital malignancies. This cohort study investigated the genotype-specific prevalence of HPV infections in a large cohort of female renal transplant recipients (RTRs). Participants self-collected a cervicovaginal sample for detection and genotyping of HPV. Besides, they completed a questionnaire regarding sociodemographic variables, medical data and sexual behavior. Anogenital screening was offered to all HPV-positive participants. A total number of 218 female RTRs were included. The prevalence of mucosal HPV infections was 27.1% and 17.4% for high risk HPV in particular.