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Significance of Breslow Density as a New Prognostic Feature in Cutaneous Melanoma

Ilke Evrim Secinti, Didar Gursoy, Tumay Ozgur, Esin Dogan

Breslow density is a novel biomarker for the assessment of tumor load in cutaneous melanoma cases. Breslow density is measured in the deepest invasive area that Breslow thickness was measured in the formalin-fixed paraffin-embedded sections. The determination of Breslow density is a simple, low-cost, and reproducible method. Interobserver compliance and accuracy rates are very high. Studies in the literature have reported that high Breslow density is associated with poor prognosis and is a predictive biomarker of short survival. Considering the prognostic and predictive value of Breslow density and the strong interobserver agreement, documentation of Breslow density in the pathology report would contribute to the prediction of the prognosis.