Журнал новых физиотерапевтических методов

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Subclinical Processes in the Development of Type Two Diabetes

Thiago Gomes Heck, Mirna Stela Ludwig, Greice Franciele Feyh dos Santos Montagner and Matias Nunes Frizzo

The imbalance in metabolic homeostasis in type 2 diabetes (T2DM) is accompanied by cellular stress, altered expression and circulating concentration of heat shock proteins (HSP) and cytokines (pro and anti-inflammatory). Also T2DM subjects had altered redox state (oxidative stress) and erythrocytes parameters. This set of molecular, biochemical and immuno haematological alterations are usually subclinical events, but characterizes chemical and biological processes associated with the development of insulin resistance and the pathophysiology of T2DM. These process and markers of T2DM complications and development will be briefly outlined throughout this mini-review article. The establishment of new strategies for glycemic control required more attention and more studies about inflammatory related biomarkers in T2DM.