Журнал молекулярной фармацевтики и исследований органических процессов

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Sustained Release of Ibuprofen by a Novel Formulated Hydrogel Containing Graphene Oxide

Amtul Jamil Sami, Madeeha Khalid, Sitara Nasar, Hummad Ahmad Mangat and Yasha Nazir Butt

Ibuprofen is a common hydrophobic drug with antipyretic and anti-inflammatory activity. The oral administration of ibuprofen is linked with gastric disturbances, which could be overcome by using a transdermal patch for site specific delivery. To bypass the gastro intestinal tack, it is required to use the transdermal route for drug delivery. The drug has poor solubility at acidic and physiological pH, which hinders the drug availability when used in dermal cream. For the sustained drug delivery, hydrogel was designed, containing Graphene oxide, chitosan and poly-acrylamide. The novel formulated hydrogel was characterized for physical properties using FTIR and SEM which confirms bonding pattern and dispersal of Graphene oxide layer on the top of hydrogel platform. The swelling properties were also studied at different pH values. The graphene oxide added hydrogels gels were able to facilitate the sustained release of Ibuprofen drug molecule, when avian skin was used as a model. Graphene Oxide (present in the hydrogel) interacts with the lipid bilayer membrane of avian skin model and enables the release of drug. The drug release was monitored by taking absorbance at 221 nm, after specific intervals. The results showed that the drug started releasing continuously, and kinetics studied. The FTIR analysis of the hydrogel before and after drug release is reveals that there was no physicochemical incompatibility between the drug and the hydrogel. It was confirmed from the results that chitosan, acrylamide, and graphene oxide based hydrogel could be successfully used for the sustained drug delivery of ibuprofen. This study could lead to the production of dermal patches for ibuprofen with minimum or no side effects. Tests showed that the released drug retained its biological activity. Such a method can be useful for the treatment of musculoskeletal inflammation which can be seen in diseases as gout and arthritis. To the best of our knowledge this is first report on the application of GO for sustained release of Ibuprofen through hydrogel when used as a dermal patch on an avian skin model.