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Synchronous HPV-Positive Squamous Cell Carcinoma of the Bilateral Base of the Tongue

Takatsugu Mizumachi, Tomohiro Sakashita, Yusuke Hishimura, Tomohiko Kakizaki, Akihiro Homma, Tomoko Mitsuhashi and Satoshi Fukuda

Although there have been several reports of synchronous Human Papillomavirus (HPV)-associated tonsillar carcinoma, no reports have shown synchronous HPV-associated Base of The Tongue (BOT) carcinoma. Here we discuss a case of synchronous HPV-associated BOT carcinoma and review the literature concerning HPV-associated second primary tumors. We report the case of a 59-year-old man with synchronous HPV-positive Squamous Cell Carcinoma (SCC) of the bilateral BOT. Both BOT SCCs were positive for HPV16. The patient received concomitant cisplatin radiotherapy, and remains disease-free at 18 months post-treatment.