Журнал терапии ожирения и снижения веса

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The Correlation between Overweight and Obesity with Plasma Levels of Leptin, Insulin and SdLDL in People Over 20 Years Old

Aazam Najmafshar

The aim of this study was to co-analysis of sdLDL, leptin and insulin at a time and their association with overweight.
 
This experiment was performed as a case-control on normal people visited Bu-Ali Hospital of Zanjan. Two hundred and thirteen individuals over 20 years old were analyzed totally from which 122 individuals with BMI ≥ 25 and 91 individuals with BMI<25 were assigned as case and control groups respectively. Height, weight, blood pressure and waist circumference of all individuals were measured. The quantitative measurement of the plasma level of leptin and insulin were performed with the ELISA method and the measurement of sdLDL was accomplished with the column method (sdLDL-C SEIKEN Kit from DENKA SEIKEN CO., LTD., Tokyo, Japan). The plasma level of glucose, triglycerides, cholesterol and HDL were measured enzymatically.

Among all variables, only triglycerides and waist circumference were independently associated with overweight and the effect of other variables were not independently associated with overweight, although it showed direct association with Body Mass Index. It seems that the correlation of other factors such as sdLDL, leptin and insulin with overweight is dependent to sex and age.
 
Our findings showed that each of these factors were correlated with the Body Mass Index; however, the logistic regression analysis revealed that age, sex, triglycerides and waist circumference are independently associated with overweight.