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The Genetic Polymorphisms of TERT-CLPTM1L and Lung Cancer Susceptibility: A Meta-Analysis

Sensen Cheng, Fuxia Wang, Bao Song and Jie Liu

Objective: To assessed the loci of the association between the single three polymorphisms (SNPs) (rs2736100, rs402710 and rs401681) and lung cancer risk. Methods: We performed a comprehensive meta-analysis of 19 publications with a total of 32,319 lung cancer cases and 5, 0529 controls via Medline, PubMed, Elsevier and Web of Science. We assessed the loci of the association between the single three polymorphisms (SNPs) (rs2736100, rs402710 and rs401681) and lung cancer risk using dominant model and performed subgroup analysis by cancer pathology and ethnicity. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using review manager 5.2 package and Stata12.0 package. Results: Overall, significant associations were observed for rs2736100 and rs401681 polymorphisms of TERT-CLPTM1L with increased lung cancer risk (for rs2736100, OR=1.32, 95% CI=1.27-1.36, P<0.00001; for rs401681, OR=1.19, 95%CI=1.12-1.26, P<0.00001). When stratified by ethnicity, rs2736100 polymorphism was associated with increased risk of Asians (OR=1.42, 95% CI=1.36-1.49, P=0.06); When stratified by pathology, there was no significant associations were found between rs2736100, rs401681 and lung cancer and lung adenocarcinoma. Conclusions: TETT-CLPTM1L is a candidate susceptibility gene for lung cancer risk in Caucasian and Asian populations. Increased cancer risk was found in rs2736100CC and rs401681CC and homozygous variant genetic model.