Международный журнал воспаления, рака и интегративной терапии

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The History of Low Dose Medicine Research Review of Preclinical and Clinical Studies with Low Dose SKA Cytokines Since 2009

Fioranelli M and Roccia MG

Since the second half of the 80s the development of the Psycho-Neuro-Endocrine-Immunology concepts resulted in a change of perspective, from a separatist point of view to an unifying one, relating to the interpretation of the biological functions of the body. A key point was the recognition of the importance of continuous cross-talk between cells, organs and systems in both physiological and pathological conditions based on the fine regulation of the levels of a large number of messenger molecules. Interpreting the pathological phenomenon as an imbalance in intercellular signaling, the administration of low physiological doses of messenger molecules (which act as homeostatic modulating agents) can be considered an intriguing and innovative approach in order to restore the correct intracellular signaling and consequently to restore healthy conditions; these concepts are the milestones of Low Dose Medicine. Five years of scientific research in the field of Low Dose Medicine demonstrated the validity of the conceptual approach and efficacy and safety of the therapeutic intervention based on the oral administration of low doses of activated messenger molecules. This review summarize for the first time the Low Dose Medicine scientific studies published since 2009 and gives a comprehensive overview of the basic and clinical research methodological approaches and results, highlighting the effectiveness of the experimental and clinical use of low dose activated messenger molecules.